Why is it so important to treat MCAS?
Hi, Remission Biome. So what are the three M’s? The three Ms of ME/CFS management are Mast cells, Microglia, and Mitochondria. The three Ms are incredibly important as a package. And, this is because mast cells, microglia and mitochondria interact in very insidious ways in terms of chronic illness. And, we can’t just manage one of them. We actually need to manage all of them.
So, when you ask this question to yourself “Where do you start with treatment?”, it gets really complex. Because, you kind of have to start everywhere and this is why the gut-brain axis prep in the Remission Biome protocol actually treats neuro prep, vagal prep, gut prep and MCAS prep together under this category of gut brain axis prep. But, to understand why gut-brain axis prep is so important and why treating MCAS is foundational? It really needs to be the first step forward in any good management plan for ME/CFS and Long Covid even if you don’t think that you have it, even if you don’t think that you actually have active allergies. You really need to focus on this mast cell-microglial interaction.
Now, the way I want you to think about this is is that we have mast cells all over our body. They’re in all of our tissues. They’re are in our dermis. They’re not in our bloodstream. They’re surrounding our organs in the dermis, they’re in our skin in the dermis. And they’re in very high abundance and density around openings such as the oral cavity, the eyes, the nasal passages. And, one of the things that happens in 2 main areas of the body is that they interact with glial cells. So, in the brain, in the central nervous system, the mast cells are interacting with microglia. And, when the microglia get activated by mast cells, they then increase some of the inflammatory factors and they activate the mast cells in this feedback loop. So, you got mast cells activating microglia and then microglia activating mast cells and this is why it’s incredibly hard to treat inflammation, neuroinflammation in the brain. A very similar process happens in our guts because of the enteric nervous system. So, you recall that there are 2 main nervous systems in the body. There’s the CNS, the central nervous system and of course there’s the peripheral nervous system which is attached to it. But, there’s also this additional nervous system which actually resides in our gut and we actually have more nerve cells in our guts than we do in our spinal cords. And this is really why brain health begins in the gut. So, in the gut, we actually have tons of mast cells because this is one of these first line systems that deals with invaders. And, mast cells of course are part of your immune system. They’re on the lookout for invasive and dangerous antigens entering the system so that they can actually deal with them. They’re like sentinel cells or like guard dogs in our bodies. So, the mast cells are in huge abundances in our guts and the mast cells themselves get activated in this inflammatory cycle with enteric glial cells which are very similar to the microglia in the brain. So, once again, you get this feedback loop where you have mast cells activating enteric glia and enteric glia interacting with mast cells. And this may be one of the reasons why it’s much harder to treat mast cell issues when they’re focused in the GI or in the brain. Of course we can get mast cell reactions in various other tissues. Skin is obviously a big one, eyes are a big one. But, it might actually be simpler to treat mast cell overactivation in certain tissues such as the skin, whereas treating it in the brain and in the gut is going to be much more involved and is going to take longer.
Well, I hope this was helpful. I hope this helps you to understand why this three Ms are such critical components of the management of ME/CFS in Remission Biome and I hope you guys have a really great day. Bye, Remission Biome.
Why treating MCAS is the foundation of treating ME/CFS?
Hi, Remission Biome. Today, we’re talking about why treating MCAS is the foundation of treating ME/CFS. Their way I want you to think about it is this, okay, this is kind of a chicken and egg question. What came first? The chicken or the egg? And, we can ask the same question. Well, what came first? MCAS or ME/CFS? Thing is, we can’t actually answer the chicken and the egg question. But, we can answer the MCAS question in relation to ME/CFS and Long Covid. So, what came first? ME/CFS or MCAS?
Well, The way I want you to think about it is this. MCAS, mast cell activation syndrome exists on a spectrum. At one end, we have very very severe MCAS. And, on the other end you have some mast cells that are activated and are releasing modulators. Now, everyone has mast cells. They’re in all of your tissues. They’re in your dermis and they’re always there. These are immune cells. These are cells that are looking out for invaders. They’re sentinel cells. They’re guard dog cells.
One of the things that we’ve discovered with Long Covid in particular is that the cytokine storm associated with the acute phase mobilized a lot more mast cells than most other infections. So, what happened here is there was an overshoot. The cytokine storm did its job. It mobilized the mast cells and told them “Hey, make more functioning mast cells. We need help to clear this virus”. Unfortunately, they created too many mast cells, in too many places, in too high of densities and abundances. And these mast cells then start releasing histamine tryptase, all these other mediators and they keep the system in a state of allergy-like reactivity, sensitivity and it just never seems to calm down. So, you actually have MCAS or mass cell activation syndrome in part because of the actual acute infection. Once this doesn’t go down, it’s considered a syndrome. Normally, this would just be a normal physiological reaction part of our immune system, how we fight viruses. No big deal.
So, mast cells and the activation that’s going on in your body actually needs to be treated in order for us to actually increase your baseline in ME/CFS and Long Covid. And, this is why we consider mast cell treatment foundational for Remission Biome. Even if you think that you don’t have mast cell activation syndrome and you may not, you may just have activated mast cells you need to treat those activated mast cells. Those activated mast cells are pumping out a lot of histamine into your body. And, histamine is a good thing. It’s something that we need. But, it also leads to allergic type reactions, increased sensitivity. And you start reacting to foods, supplements, medications, even hot and cold. It also massively upregulates your sympathetic nervous system leading to anxiety like states and panic attacks. And, the only way to actually start to get this under control is to treat the mast cells.
Mast cell activation also underlies the insomnia that most of us experience and the sleep dysfunctions. Particularly, these night time awakenings at like 2-3 in the morning. This is a histamine response. Because, histamine itself is on a circadian cycle And, when we mess with our circadian cycles as we do with chronic illness. We actually start to push it off track and it starts to increase in its dysfunction.
So, really when you start to think about “Well, l do I treat ME/CFS or MCAS? Do I need to treat MCAS?”. The answer is yes. You may not have the syndrome but you have activated mast cells. This is part of the disease process of managing infection. Well, I hope this was helpful and i hope you have a really great day. Now, control your mast cells. Bye, Remission Biome.
How do we actually treat MCAS in the Remission Biome protocol?
Hi, Remission Biome. Today, we’re talking about MCAS, mast cell activation syndrome and why dealing with MCAS is foundational as part of the Remission Biome protocol. So, how do we actually treat MCAS in the Remission Biome protocol?
The most important product is called FibroProtek. This is a product that was designed and formulated by Dr. Theo Theoharides. And, he started working with a company called Algonot to make this product. Now, Algonot makes many different products and they’re all great for treating mast cell activation. Some of them have low phenols, some of them have more of some ingredients and less of the others, some come in drop some come in capsules and there are affiliated products as well such as skin creams and specific products to treat and manage viral infections such as Covid. One of the products there is called ViralProtek. Now, we use ViralProtek and FibroProtek specifically in the Remission Biome protocol to control mast cell activation. And, even if you don’t have mast cell activation syndrome or have allergy type reactions, we still want you to use these two products because they are part of the protocol. And, keeping mast cells in control is actually a fundamental part of the treatment as a whole because mast cells interact with microglia in the brain and enteric nerves, enteric glia in the gut. And, they increase inflammation in both of those areas and reactivity.
Now, for many of us, because MCAS is on a spectrum from constantly flaring to very very mild, FibroProtek might not be enough and you may need to layer in other medications and supplements. This is obviously where you’re going to want to have a conversation with your GP. But generally, the recommendations for MCAS are H1 and H2 antihistamines, mast cell stabilizers such as ketotifen, combined mast cell stabilizers and antihistamines such as rupatadine, over the counter oral spray NasalCrom. And the ingredient in NasalCrom is sodium cromoglicate and this can actually be taken orally in capsule form or in a liquid form. Unfortunately, it doesn’t have good bio absorption in the gastrointestinal tract. Only about 10% of it is actually absorbed. So, getting it through the nasal cavity is actually a much better way of getting sodium cromoglicate into your body. Various people are going to need various combinations of all of these meds and they can add specific flavonoids, as well.
We all know that quercetin is great for treating MCAS. But luteolin which is what is used primarily in the Algonot products as part of a combined quercetin, rutin, luteolin group is even more effective. And, the bio-availability and formulation of the specific flavonoids in the Algonot products really is top-notch. There’s no other products like them out there. And so, working with Algonot and Dr. Theo has really been an incredible thing for us at Remission Biome. It’s probably going to be one of these considerations where you’re going to play around with different H1 and 2 antihistamines until you find the right combination that works for you, for both night and day. And, it’s very important to actually have an MCAS protocol as kind of a rescue med stash. Because, many of us will experience random flares of MCAS and getting these under control as quickly as possible is very important. Because, it’s during flares where the body mistakes much more easily, non-infectious antigens such as foods for invaders and starts to create these sensitivity cascades that lead to poly reactivity and loss of oral tolerance.
So, working with your GP is important but of course, many of these medications and supplements are available OTC. So, don’t let- that stop you but please watch the videos that we’ve put on on MCAS and do talk to your doctor about MCAS treatment, particularly mast cell stabilizers. There are no great mast cell stabilizers that are available OTC. So, for things like ketotifen and other mast cell stabilizers, you will have to talk to your GP. Luckily, because you’re working with Remission Biome, you have a GP on side.
Well, I hope this was helpful and I hope you have a really great day. Treat that MCAS.
What is well-controlled MCAS?
Hi, Remission Biome. Today, we’re talking about MCAS and the foundational treatment of MCAS as part of the Remission Biome protocol. It’s really important in the Remission Biome protocol to control your MCAS. And, we often say you should only do the acute phase once your MCAS is properly controlled.
So, what does this actually mean? How do you determine if your MCAS is under control or not? Well, if your MCAS is under control, you’re not flaring, you’re not actually getting symptoms related to MCAS. So, your gut problems would have calmed down. You’re not getting food sensitivities, you’re not getting sensitivities to medications and supplements, you’re not getting sensitivities to heat and cold. If your MCAS is not flaring, you wouldn’t be getting rashes, you wouldn’t be getting allergy type effects around your eyes and you wouldn’t be getting inflamed tissues around your nasal passages, you wouldn’t have loss of oral tolerance, you wouldn’t be feeling like your body is constantly anxious, your sleep disturbance would have calmed down a bit, you would feel that you have sort of more control. What you’re putting into your body isn’t actually making your body more reactive.
Obviously, this is not an easy thing to get your head around. Is my MCAS controlled or not? Because all of these symptoms are also symptoms of ME/CFS. So, how do you know if your symptom is caused by ME/CFS or it’s caused by MCAS? Well, you can’t know 100%. But, when you did your challenge tests and you actually used the MCAS protocol to figure out where you were on that MCAS spectrum and if you were experiencing mast cell activation syndrome, you should have actually got a feeling for how likely it is that some of your symptoms are due to MCAS and some are not.
So, for example, when we use the challenge test and this is a normal sort of way that clinicians and doctors test the efficacy and diagnosis in the clinic is they actually treat it. So, for example, if they wonder do you have MCAS instead of doing a test which is going to be tricky and might not yield a definitive answer, instead they’ll actually say “Well, why don’t we just treat it and see if it goes down?”. So, when you’ve done this yourself and you’ve treated the MCAS using the challenge test, you should have figured out “Hey, when I take these antihistamine combinations, I actually start sleeping better and I’m no longer feeling so anxious”. So, you can actually attribute some of those symptoms to MCAS rather than to other things. So, you should have gotten some sense and this is really why symptom tracking is so important as part of Remission Biome protocol. Because, you actually really have to get to know your own body, your symptoms and what causes you to have flares.
Well, I hope this was helpful and I hope you all have a really great day. Bye, Remission Biome.
MCAS and diet
Hi, Remission Biome. Today, we’re talking about MCAS and why MCAS is so foundational in the Remission Biome protocol and this video specifically is going to focus on diet. Now, most of us don’t want to deal with this piece. But we’re having food sensitivities and we’ve developed new food sensitivities since getting sick. This is a signal that you actually do have to control your diet, to control your MCAS. And this is really the first line thing that you want to do as part of the challenge test and the kitchen sink approach to actually treat your MCAS.
As hard as this is going to be, we recommend that you remove soy, corn, wheat and dairy from your diet for a couple of weeks during the Remission Biome protocol. And then, you add these groups back in once at a time, once every few days and you see if you have a reaction. These may not be food sensitivities that will exist for your entire life. But, they may be food sensitivities that you have now and it’s incredibly important to deal with them not just because they’re uncomfortable but because they can actually increase the chances of you developing out of control polyreactivity where you start to react to everything.
So, completely cutting out wheat, dairy, soy, corn and for some people eggs is incredibly important. If you think that these are issues for you, they probably are and you need to cut them out. Before you treat MCAS with antihistamines, mast cell stabilizers or any of the other recommended OTC supplements such as NasalCrom, doing this food challenge is incredibly important. This is called an elimination diet and you may not have to do it for longer than a couple weeks. We recommend that you do it early on in the protocol and you do it incredibly strictly. The goal here is to identify if you’re having a food sensitivity. And, if you are having a food sensitivity we can be fairly sure that this food sensitivity is contributing to leaky gut. Leaky gut of course is one of the most important things that we treat in the early stages of the Remission Biome protocol in the gut prep phase. And, treating leaky gut is completely critical because we need to lower the amount of something called lipopolysaccharides or LPS that get into your bloodstream. These are nasties that are actually created by bacteria getting into the bloodstream and they can actually stop the acute Remission Biome event from happening, at least we think they can. They definitely did for me.
So, unless you’re controlling MCAS, controlling the food sensitivities and correcting the leaky gut, the acute phase might not work as well or might not work at all. Because, this is such a big deal we want to make sure that this is not a contributing factor for anyone. So, doing an elimination diet for a couple of weeks early on in the Remission Biome protocol is recommended. We know it’s difficult, we know you don’t want to do it but if you still have constipation, diarrhea, gut issues, if you’re still not sleeping correctly, if you’re still getting anxiety and panic attacks, you can be sure that this is one of the things that’s contributing to it and needs to be addressed.
Well, I hope this was helpful and I hope you have a really great day. Bye, Remission Biome.
A challenge test to determine if you have MCAS
Hi, Remission Biome. Today we’re talking about treating MCAS and how foundational MCAS is to management in the Remission Biome protocol. One of the things that we want you to do in the Remission Biome protocol is to do a challenge test. You’re going to do this hopefully under the supervision of your GP. And, this is where you actually test to see how severe your MCAS activation actually is. Because, we know that MCAS activation is part of the normal disease process is actually part of your immune system dealing with an infection but overshooting and creating too many mast cells, we know that all of us actually need to get this under control and to treat it. But of course, MCAS exists on a spectrum. Some will have constant flares, some will have very mild MCAS and during the course of your illness it may move along the spectrum all the time.
It’s very helpful to run what we call the challenge test. This is a typical method used in medicine where you actually diagnose the condition based on seeing if it responds to a treatment. Now, with MCAS, it’s a little bit more complicated because we’re not just asking your doctor to provide one medication and see if it actually works.
To properly treat MCAS, you need a number of different pieces. You need H1 and H2 antihistamines. Potentially, you need mast cell stabilizers. Potentially you need things like NasalCrom, nasal spray. You need flavonoids such as quercetin and luteolin. And, for some of us, we may need all of these things and we may need higher dosage. And some of us may only need certain ones. We know that MCAS is one of these pretender diagnoses and I don’t mean it’s pretend diagnosis. I mean it pretends to be many other different things. We can attribute GI dysfunction, diarrhea and constipation to MCAS. We can attribute headaches to MCAS. There’s a huge neurological component. We can attribute skin rashes to MCAS, redness around the eyes to MCAS. We can contribute tachycardia to MCAS, POTS to MCAS.
So, MCAS is really the great pretender and one of the big questions we have in ME/CFS and Long Covid are all of these comorbidities that we think we have actually separate syndromes or diseases? So, one of the really helpful things that you can do early on is you can figure out, for example, whether you have POTS or whether you have tachycardia due to MCAS. To figure this out is actually not as hard as you might imagine. Because, you can do a challenge test, you can treat the MCAS. You can add the H1 and H2 antihistamines. You can add the mast cell stabilizers. You can add the flavonoids. And, if the anxiety and panic attacks go away, well, you can answer the question were they due to MCAS. In this case, yes, you might be surprised. Much of the insomnia, anxiety, gut issues that you’re actually experiencing could be due to MCAS. It’s really worth figuring this out.
Obviously, we recommend that you do the challenge test with your GP. There are a lot of different antihistamines out there. There are a lot of different combinations that might be worth looking at. And your particular presentation of mast cell activation where it seems to be focused in the body, what organ systems it’s affecting the most, whether you also have allergies, all of these things are going to play in and you really want to put together a kind of a plan to run the challenge test to see whether some of your symptoms are actually due to MCAS or are actually comorbidities such as POTS or even PTSD. So, talk to your doctor about running a challenge test. This is a concept that they’re familiar with. So, you’re actually speaking medically when you talk about challenge testing.
I hope this was helpful and I hope you have a really great day. Bye, Remission Biome.
Is your headaches due to MCAS? Do a challenge test
Hi, Remission Biome. Today we’re talking about mast cells and why treating mast cell activation syndrome is so fundamental to the Remission Biome protocol. This video specifically is going to be on mast cells and neurological manifestations. When we think neurological manifestations, it’s kind of big.
What are we talking about? Well, really? We’re talking about headache and brain fog. And surprisingly, there is a very strong link between headache, mast cells, and neuroinflammation and brain fog. So, if you’re experiencing daily headaches and daily migraines, some of it actually could be due to mast cell activation syndrome and doing a challenge test and ruling this in or out is incredibly important. You want to know if your headache is in fact due to mast cell microglial neural inflammation and there’s a very strong possibility it is. Now, mast cells can also have other neurological consequences. They can increase anxiety, they can cause mood disturbances and they can even lead to psychosis in very extreme cases. We often discount the neurological manifestations of mast cell activation as due to something else, some other process. And, we don’t think that it’s worth treating it. But in fact, treating mast cell activation syndrome is completely foundational in terms of treating ME/CFS and its manifestations. You really want to figure out what symptoms you have are due to mast cell versus what symptoms you have are due to ME/CFS.
If it’s as simple as treating mast cell activation to get rid of headaches and migraines, anxiety and panic and depression. Well, I really do think that this is the first thing that should be tried. So, if you’re experiencing daily headaches, migraines, mood disorders anxiety or panic, these are all neurological manifestations. And of course, we always want to be on the lookout for more extreme ends of these spectrums such as psychosis. Neuroinflammation does lead to these types of symptoms. This is brain on-fire which I’m sure you’ve heard about before. So, treat mast cell activation, run a challenge test. See if it helps your migraines and your other neurological symptoms. I think you’re going to be glad that you did.
Hope this was helpful and I hope you have a really great day. Bye, Remission Biome.
How to avoid possible mast cell flares while you’re doing the acute phase of the Remission Biome protocol?
Hi, Remission Biome. Today we’re talking about MCAS and why treating MCAS is so foundational in the Remission Biome protocol. Now, all treatment has risks this is just inherent. Everything in life does have a risk. But, we can lower the risks of certain things happening first by being aware of them, second for testing to make sure that we can that pre-existing condition isn’t going to happen and third making sure that we have things on hand that can help if we do have the side effect. One of the things that we are concerned about in the Remission Biome protocol, our mast cell flares while you’re doing the acute phase. And this is because it is a known feature of antibiotics that they can increase mast cell flares.
So, we want to make sure that you don’t have uncontrolled MCAS going into the acute phase. We want to make sure that you have rescue meds around in case you do and these include antihistamines. And, we actually use a test before you do the acute phase to make sure that you don’t have something called polyreactivity. This is the test that we’re using from Cyrex called the Array-14. And, the Array-14 is a test of your mucosal membranes and it helps determine whether your mucosal system is managing antigens, things from the environment and whether or not they’re seeing these chemicals from the environment and other things from the environment as invaders and creating antibodies against them. The Array-14 is an interesting test because if you have something called polyreactivity, you will actually show up as in the red for every single one of the triggers. Normal people will have a max of yellow, red and green. So, normal results, equivocal results and high results. But, for someone who’s polyreactive, their entire test will come back with high or equivocal results. If this is the case, you’re actually part of about 5% of the population that is born with polyreactivity. And, in some of these people it’s actually protective rather than a deleterious mutation. But, we need to make sure that you particularly don’t have a new emergence of polyreactivity before you go into the acute phase. So, this is what Array-14 does for us. So, Array-14 is kind of like a safety test. We use it to make sure that you don’t have leaky gut which would also increase the chances of their Remission Biome protocol not working, as well or not working at all. And, it also helps us determine if you have polyreactivity and what you’re actually reacting to. So, the Array-14 has a number of different categories for chemicals, mycotoxins, foods and other infectious diseases to make sure that your system is not creating auto antibodies to these different antigens.
Well, I hope this was helpful and I hope you have a really great day. Bye, Remission Biome.
Planning for negative side-effects as a crucial part of the Remission Biome protocol
Hi, Remission Biome. Today, we’re talking about mast cells and why treating mast cells is so fundamental as part of the Remission Biome protocol.
One of the main reasons why we’re so focused on mast cells is because mast cells interact with microglia and they maintain patterns of neuroinflammation and gut inflammation. So, managing MCAS and controlling MCAS is really a fundamental part of the Remission Biome protocol. But, there’s also a reason why managing and controlling MCAS is important in addition to this basic foundational approach. And this is because it is known that in rare cases, antibiotic use can increase MCAS flares. In this case, you want to make sure that you have rescue medications around, so antihistamines around and mast cell stabilizers in case you do get a flare of MCAS during treatment with antibiotics. Because, this is a possible side effect of the acute phase of the Remission Biome protocol. We want to make sure that when you’re going into it, your mast cell activation, if you have any is very very well-controlled. And, because this is part of the normal disease process of infection and the immune system, we know that you do have some mast cell activation going on.
So, treating and managing MCAS and going into the acute phase with well-controlled MCAS is incredibly important. There is a chance that you could get an MCAS flare when you take antibiotics. This is a known rare side effect of antibiotics. So, having the rescue medication around is very important in case this actually happens. We are also concerned about treating MCAS because of something called poly-reactivity and loss of oral tolerance. And, when you consistently have these immune reactions, these antibodies being built up to different antigens coming into your body, you can actually get an increase in your symptoms over time as you keep having flares. These flares can keep building and keep building, your food sensitivities can keep building and building and eventually you can get to a place where you start reacting to absolutely everything. Of course this is one of our nightmares in ME/CFS and it’s one of the things that we most worry about. There’s a couple of things that we can do to lower the chances of this happening. One is to treat MCAS even if you think you might not have it. Do a challenge chest, figure out if mast cell activation really is an issue for you, also have rescue medications around in case you have a flare. And, when you’re having a flare, don’t eat things like wheat, dairy, soy or corn or anything else that you know would activate your mast cells. In these cases, we want to be really careful to only put things into our system which our system will see as safe.
So, having well-controlled MCAS is important going into the acute antibiotic phase for a number of different reasons. And, it’s very important to work with your doctor and talk to them about MCAS so that they understand some of the risks and how to ameliorate them going forward. I hope this was helpful and I hope you have a really great day. Bye, Remission Biome.
How to talk to your doctor about MCAS as part of the Remission Biome protocol?
Associate MCAS, mast cell activation syndrome with pseudoscience and alternative medicine however this is not the case. Mast cells are real cells in your body just like any other cell from the myeloid line. They’re just not as well understood. Mast cells are part of your immune system. They’re sentinel or guard cells. And, when we get sick, the body makes more mast cells to help deal with infection and invaders.
In med school, your doctor is probably been taught about mastocytosis and IgE-mediated mast cell allergies. Mastocytosis is a particular type of mast cell disorder, very rare, only seen in about 2.7 people in every million and you’re born with a higher number of mast cells in your body than other people. This is a life-threatening condition and you cannot develop it during the course of your life. Mast cell activation of course is something that you can develop and you can develop that following an infection. And so, talking to your doctor about it is incredibly important.
One of the things that you can suggest to them is that you do a challenge test. And, you just try out antihistamines and mast cell stabilizers and see if some of your symptoms are due to MCAS. If some of your symptoms decrease this does provide some evidence that maybe MCAS is driving some of your symptomatology. You can also do a challenge test on various types of antihistamines and various dosages. And, there’s a lot of optimization that can be done here depending on where in the body your mast cell activation is primarily located gut, brain, skin, around oral openings and you can actually adopt an antihistamine regime for day night to help with insomnia, to help with anxiety and panic. Different medications work better for some rather than others and some need different dosages. So, this is really an example here of personalized medicine and challenge and dose testing is really the way to go. There’s no one treatment but we do consider that there is a kitchen sink approach. This means you throw everything at it. You do an elimination diet and you try to control the food sensitivities. Then you do the H1s, the H2s, the flavonoids and the mast cell stabilizers.
It’s really important as patients that we talk to our doctors about concepts that they might not have been taught in med school. It definitely helps other patients down the line. There’s a lot of really great information on mast cell activation syndrome for physicians and doing a google scholar search yourself and bringing some of these papers along might be what you need to do. Also look at the research work done by Dr. Theo Theoharides. He has published many laypersons descriptions of mast cell activation syndrome, many guides to clinicians and review articles that can help get their head around just how different mast cell activation is to IgE mediated allergy or mastocytosis. Your doctor’s right. Mastocytosis is incredibly rare and it’s very unlikely you have it. But, it’s incredibly likely that you do have mast cell activation.
We know that mast cell activation is associated with the body’s program to fight infection. It’s part of the immune system. So, your mast cells are activated. Do you have mast cell activation syndrome? Well, we don’t know. This is something that you’re going to need to find out. And, your doctor can help you do a challenge test.
I hope this was helpful and I hope you have a really great day. Bye, Remission Biome.