Hi, Remission Biome. Today I want to talk about dose dependence. Dose dependence essentially describes the concept where we need to take a certain amount of a substance for it to actually have the required mechanistic effect that we’re looking for. It applies to all molecules that we put in our body and we have to do cost-benefit analysis on all the different interventions that we use because there are negative side effects associated with almost everything.

So, you really have to look at the molecule that you’re thinking about using, the supplement you’re using, look at the minimum dosage that’s actually going to work in terms of what you’re trying to move in terms of your system. And then, you need to figure out how you can get to that minimum required dose.

So, one of the issues that we all seem to deal with is that we’re supersensitive to medications and supplements and foods. And, this is a a feature of MCAS, mast cell activation syndrome. If you are reacting to a wide range of supplements and medications, it’s almost for sure that you have MCAS reactions going on. And so, the first thing that you need to do is you actually need to get the MCAS under control. When you get the MCAS under control, you’ll then be able to reintroduce some of these medications and supplements that before you weren’t tolerating. And importantly, you’re going to be able to reintroduce them at dosages that actually do something in your body. If you cannot take a certain level of medication or supplement, it’s not just that it’s going to work less well. It’s that it’s actually not going to work and you’re not going to get the desired result. This is dose dependence and it’s an incredibly important part of pharmacology and treatment. It’s going to be different for every molecule you look at and it’s very standard.

So, we as humans don’t have an hugely wide range of doses where something becomes effective. It’s going to be pretty standard across the board with some variation that we all start to react negatively or positively to a medication at a certain level. Now, the thing that interferes with this of course is tolerance due to MCAS and other quirks of our physiology. So, there’s always some play there. But for example, if you’re taking Resveratrol and you’re taking it for cardiovascular health and endothelial health, you really need to be taking about 1000 milligrams a day. That’s huge, right? Because many of you are probably taking 50 milligrams or 100 milligrams. Maybe you’re taking 250 milligrams. And then you thought that you were really pushing it. But, the research shows that if you’re looking to correct endothelial damage with Resveratrol, you’re going have to take a higher dose. If you’re using it for a general health and longevity, you’re going to have to take a higher dose. And, if you’re taking this tiny dose, yes you may not react to it but you also may not be getting any of the positive benefits that you’re hoping to get from it either. So, it’s really something that you need to consider with every med, every supplement dose dependence. Well, I hope this was helpful and I hope you have a great day. Bye, Remission Biome.